Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7718954 | 0.91 | PDE10A (0.48) | PDE2ACYP1A2PDE10AFGFR1HDAC8 | |
| SCHEMBL7717836 | 0.90 | PDE10A (0.51) | CYP1A2PDE10AFGFR1ACSS2DRD2 | |
| SCHEMBL2324702 | 0.88 | TP53 (0.47) | PDE2ATP53 | |
| SCHEMBL7719701 | 0.87 | FGFR1 (0.52) | CYP1A2PDE10AFGFR1ACSS2DRD2 | |
| SCHEMBL2323606 | 0.86 | LTB4R (0.48) | PDE2AACSS2HDAC8TP53 | |
| SCHEMBL2323156 | 0.85 | TP53 (0.40) | CYP1A2PDE10AACSS2TP53DRD2 | |
| SCHEMBL7719698 | 0.85 | PDE2A (0.42) | PDE2ACYP1A2PDE10AFGFR1ACSS2 | |
| SCHEMBL2324248 | 0.85 | PDE3B (0.42) | CYP1A2PDE10AACSS2TP53KCNH2 | |
| SCHEMBL7714523 | 0.84 | PDE10A (0.48) | PDE2ACYP1A2PDE10AFGFR1DRD2 | |
| SCHEMBL7719686 | 0.83 | TLR8 (0.42) | TP53ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246808-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051473-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-07-19 | — | — | WO | disclosed |