Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 5/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326115 | 0.86 | LTB4R (0.46) | DHFRPOLBLMNATP53SIRT2 | |
| SCHEMBL7714451 | 0.83 | PDE2A (0.43) | TP53ESR1ESR2 | |
| SCHEMBL7719681 | 0.79 | LTB4R (0.48) | SIRT2SIRT1ESR1ESR2 | |
| SCHEMBL7714453 | 0.78 | DHFR (0.44) | TLR8BCHEACHEDHFRPDE4B | |
| SCHEMBL7721733 | 0.78 | SIRT2 (0.47) | TLR8LMNATP53SIRT2SIRT1 | |
| SCHEMBL7721735 | 0.78 | SIRT2 (0.45) | TLR8DHFRPOLBLMNATP53 | |
| SCHEMBL4589206 | 0.78 | FABP4 (0.45) | SIRT2SIRT1 | |
| SCHEMBL2322819 | 0.77 | LTB4R (0.47) | DHFRSIRT2SIRT1 | |
| SCHEMBL7719714 | 0.77 | LTB4R (0.48) | DHFR | |
| SCHEMBL2328848 | 0.77 | LTB4R (0.45) | DHFRSIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246808-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051473-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-07-19 | — | — | WO | disclosed |