SCHEMBL7714549

SCHEMBL7714549

Cc1ncc(CCc2ccccc2)c(Nc2ccccc2)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AURKA O14965 2/20 0.41
CYP3A4 P08684 4/20 0.40
CYP1A2 P05177 3/20 0.40
MEN1 O00255 2/20 0.40
CYP2C19 P33261 2/20 0.40
KMT2A Q03164 2/20 0.40
CYP2C9 P11712 1/20 0.40
CASP1 P29466 1/20 0.40
CASP7 P55210 1/20 0.40
HIF1A Q16665 1/20 0.40
HSD17B10 Q99714 1/20 0.40
KDR P35968 4/20 0.40
EGFR P00533 2/20 0.40
ULK1 O75385 1/20 0.39
SRC P12931 2/20 0.39
CLK4 Q9HAZ1 2/20 0.39
TSHR P16473 2/20 0.39
MAPK1 P28482 1/20 0.39
TLR8 Q9NR97 1/20 0.38
IGF1R P08069 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6642227 0.82 PIN1 (0.51) AURKACYP3A4CYP1A2MEN1CYP2C19
SCHEMBL7714240 0.82 AGTR1 (0.48) CYP3A4CYP1A2MEN1CYP2C19KMT2A
SCHEMBL17035558 0.78 TLR8 (0.54) TSHRMAPK1TLR8KDM4ELMNA
SCHEMBL859187 0.76 EGFR (0.51) AURKACYP3A4CYP1A2CYP2C19KMT2A
SCHEMBL7714131 0.73 KDM4E (0.43) AURKAMEN1KMT2AMAPK1KDM4E
SCHEMBL5230508 0.71 EGFR (0.42) AURKACYP3A4CYP1A2CYP2C19KMT2A
Diphenylamine SCHEMBL9782686 0.69 HSD17B10 (0.67) CYP3A4CYP1A2MEN1CYP2C19KMT2A
SCHEMBL6642559 0.69 PIN1 (0.52) AURKAMEN1KMT2AKDREGFR
SCHEMBL670753 0.68 CASP1 (0.57) CYP3A4CYP1A2MEN1CYP2C19KMT2A
SCHEMBL24255306 0.68 APP (0.50) CYP3A4CYP1A2MEN1CYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1025091-A1 SUBSTITUTED PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE OR NEUROLOGICAL DISORDERS OF THE CENTRAL NERVOUS SYSTEM Krenitsky Pharmaceuticals, Inc. (US) 2000-08-09 EP claimed
WO-1999019305-A2 SUBSTITUTED PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE OR NEUROLOGICAL DISORDERS OF THE CENTRAL NERVOUS SYSTEM KRENITSKY PHARMACEUTICALS INC. (US) 1999-04-22 WO claimed
US-6440965-B1 Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system KRENITSKY PHARMACEUTICALS, INC. 2002-08-27 US disclosed
EP-1025091-A1 SUBSTITUTED PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE OR NEUROLOGICAL DISORDERS OF THE CENTRAL NERVOUS SYSTEM Krenitsky Pharmaceuticals, Inc. (US) 2000-08-09 EP disclosed
WO-1999019305-A2 SUBSTITUTED PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE OR NEUROLOGICAL DISORDERS OF THE CENTRAL NERVOUS SYSTEM KRENITSKY PHARMACEUTICALS INC. (US) 1999-04-22 WO disclosed