Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216486 | 0.81 | CA12 (0.41) | NLRP3ALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL7218351 | 0.80 | CA12 (0.52) | ALDH1A1NPC1RAB9AL3MBTL1CA12 | |
| SCHEMBL5204894 | 0.80 | NR4A2 (0.37) | ALDH1A1NPC1RAB9AL3MBTL1CA12 | |
| SCHEMBL7714495 | 0.78 | PNMT (0.35) | PNMTALDH3A1NPC1RAB9ACA12 | |
| SCHEMBL7714502 | 0.77 | PNMT (0.34) | PNMTALDH3A1ALDH1A1NPC1RAB9A | |
| SCHEMBL7712649 | 0.77 | RAB9A (0.46) | ALDH1A1NPC1RAB9AL3MBTL1CA12 | |
| SCHEMBL7378104 | 0.76 | CA12 (0.48) | ALDH1A1NPC1RAB9AL3MBTL1CA12 | |
| SCHEMBL7222816 | 0.73 | PTGS1 (0.39) | PTGS2NPC1RAB9AL3MBTL1PTGS1 | |
| SCHEMBL25554151 | 0.72 | CA12 (0.53) | CA12CA2CA9 | |
| SCHEMBL7714885 | 0.71 | CA9 (0.39) | ALDH1A1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369110-B1 | PROPHYLACTIC AGENT FOR DISEASES CAUSED BY THE ACCELERATION OF THE SODIUM/PROTON EXCHANGE TRANSPORT SYSTEM | SUMITOMO PHARMACEUTICALS COMPANY (JP) | 2002-04-09 | — | — | US | disclosed |
| EP-1083166-A1 | NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-03-14 | — | — | EP | disclosed |