Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | LIPE | Q05469 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3460086 | 0.82 | ALDH1A1 (0.43) | MAPTTDP1L3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL339812 | 0.82 | MAPT (0.71) | MAPTTDP1L3MBTL1MAPK1HTR1A | |
| SCHEMBL5538708 | 0.76 | MAPT (0.63) | MAPTTDP1L3MBTL1MAPK1HTR1A | |
| Formaldehyde SCHEMBL27831678 | 0.76 | MAPT (0.63) | MAPTTDP1L3MBTL1MAPK1SGMS2 | |
| SCHEMBL22169165 | 0.73 | BRD4 (0.55) | MAPTTDP1L3MBTL1MAPK1SGMS2 | |
| SCHEMBL28457205 | 0.72 | MAPT (0.59) | MAPTTDP1L3MBTL1MAPK1HTR1A | |
| SCHEMBL2093962 | 0.72 | MAPT (0.59) | MAPTTDP1L3MBTL1MAPK1HTR1A | |
| SCHEMBL791853 | 0.72 | HTR1A (0.74) | MAPTTDP1L3MBTL1MAPK1HTR1A | |
| SCHEMBL30416387 | 0.72 | HTR1A (0.74) | MAPTTDP1L3MBTL1MAPK1HTR1A | |
| SCHEMBL27286576 | 0.72 | MAPT (0.59) | MAPTTDP1L3MBTL1MAPK1SGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10245336-A | — | — | None | — | — | JP | disclosed |
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001051125-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-07-19 | — | — | WO | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |
| JP-H10245336-A | INHIBITOR TO NA/CA-EXCHANGE SYSTEM | TAISHO PHARMACEUT CO LTD | 1998-09-14 | — | — | JP | disclosed |