Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 10/20 | 0.38 |
| ▸ | RORC | P51449 | 6/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710617 | 0.84 | CYP11B1 (0.34) | S1PR3S1PR1 | |
| SCHEMBL7984344 | 0.84 | CYP19A1 (0.37) | RORCCYP19A1CYP3A4CYP3A5 | |
| SCHEMBL7981909 | 0.84 | ACSS2 (0.38) | RORCCYP19A1CYP3A4CYP3A5 | |
| SCHEMBL7980280 | 0.81 | FNTA (0.42) | RORCCYP19A1 | |
| SCHEMBL7714934 | 0.80 | CYP11B1 (0.34) | S1PR3S1PR1 | |
| SCHEMBL2915674 | 0.78 | CYP3A4 (0.41) | CYP19A1CYP3A4CYP3A5 | |
| SCHEMBL7713179 | 0.74 | S1PR3 (0.41) | S1PR3S1PR1 | |
| SCHEMBL7713123 | 0.72 | KCNQ3 (0.38) | S1PR3S1PR1 | |
| SCHEMBL7191177 | 0.72 | S1PR3 (0.35) | S1PR3S1PR1 | |
| SCHEMBL7677947 | 0.71 | SIRT2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297239-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2001-10-02 | — | — | US | disclosed |
| EP-1021188-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999017777-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |