Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.35 |
| ▸ | RARB | P10826 | 14/20 | 0.34 |
| ▸ | RARG | P13631 | 14/20 | 0.34 |
| ▸ | RARA | P10276 | 13/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715218 | 0.89 | RARB (0.42) | RXRARARBRARGRARACYP3A4 | |
| SCHEMBL9147995 | 0.82 | RXRA (0.38) | RXRARARBRARGRARACYP3A4 | |
| SCHEMBL7713122 | 0.82 | RARA (0.36) | RXRARARBRARGRARACYP3A4 | |
| SCHEMBL6157083 | 0.79 | RXRA (0.52) | RXRARARBRARGRARACYP3A4 | |
| SCHEMBL6157965 | 0.79 | RXRA (0.52) | RXRARARBRARGRARACYP3A4 | |
| SCHEMBL7709286 | 0.75 | CYP26A1 (0.52) | RXRARARBRARGRARACYP3A4 | |
| SCHEMBL9006909 | 0.75 | RARA (0.39) | RXRARARBRARGRARACYP3A4 | |
| SCHEMBL8681439 | 0.74 | RARB (0.41) | RXRARARBRARGRARACYP3A4 | |
| SCHEMBL7715303 | 0.73 | RARA (0.48) | RXRARARBRARGRARACYP3A4 | |
| SCHEMBL7709298 | 0.72 | RARB (0.44) | RXRARARBRARGRARACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6368608-B1 | SKIN DISORDERS | CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) (FR) | 2002-04-09 | — | — | US | disclosed |
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |
| EP-0661258-B1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CIRD GALDERMA (FR) | 1998-04-08 | — | — | EP | disclosed |
| US-5716624-A | USEFUL FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, OPTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS/DISORDERS | C.I.R.D. GALDERMA (FR) | 1998-02-10 | — | — | US | disclosed |
| EP-0661258-A1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-07-05 | — | — | EP | disclosed |