SCHEMBL9006909

SCHEMBL9006909

C#Cc1ccc2c(c1)SCCC2(C)C

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
RARA P10276 9/20 0.39
RARB P10826 9/20 0.39
RARG P13631 9/20 0.39
CYP3A4 P08684 3/20 0.39
CYP26A1 O43174 2/20 0.39
KMT2A Q03164 1/20 0.36
RXRA P19793 2/20 0.35
CRABP2 P29373 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4309215 0.87 RARA (0.50) RARARARBRARGCYP3A4CYP26A1
SCHEMBL9006923 0.79 RARB (0.46) RARARARBRARGCYP3A4CYP26A1
SCHEMBL6668874 0.76 EPHX2 (0.39) RARARARBRARGCYP3A4CYP26A1
SCHEMBL2223568 0.75 RARB (0.53) RARARARBRARGCYP3A4CYP26A1
SCHEMBL7715340 0.75 RXRA (0.35) RARARARBRARGCYP3A4CYP26A1
SCHEMBL9007043 0.75 RARB (0.67) RARARARBRARGCYP3A4CYP26A1
SCHEMBL9054573 0.75 RARA (0.37) RARARARBRARGCYP3A4CYP26A1
SCHEMBL4848764 0.75 RARA (0.37) RARARARBRARGCYP3A4CYP26A1
SCHEMBL19259616 0.75 RARA (0.37) RARARARBRARGCYP3A4CYP26A1
SCHEMBL9295885 0.74 RARA (0.35) RARARARBRARGCYP3A4CYP26A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0571546-B1 CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY ALLERGAN INC (US) 1996-10-16 EP disclosed
US-5346915-A Chromans and thiochromans with phenylethynyl substituents at the 7-position having retinold-like biological activity ALLERGAN, INC. (US) 1994-09-13 US disclosed
US-5346895-A Treating dermatoses, immunological disorders, wound healing ALLERGAN, INC. (US) 1994-09-13 US disclosed
EP-0577737-A1 CHROMANS AND THIOCHROMANS WITH HETEROARYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY ALLERGAN, INC. (US) 1994-01-12 EP disclosed
EP-0571546-A1 CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY. ALLERGAN INC (US) 1993-12-01 EP disclosed
WO-1992017471-A1 CHROMANS AND THIOCHROMANS WITH HETEROARYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY ALLERGAN, INC. (US) 1992-10-15 WO disclosed
WO-1992014725-A1 CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY ALLERGAN, INC. (US) 1992-09-03 WO disclosed