Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL194327 | 1.00 | CCNA2 (0.33) | CCNA2CDK2CCNA1CDK5DYRK1A | |
| Trifluoroacetic Acid SCHEMBL15808556 | 0.93 | SLC2A1 (0.35) | ITGB3ITGA2B | |
| SCHEMBL7719378 | 0.90 | CCNA2 (0.35) | CCNA2CDK2CCNA1CDK5DYRK1A | |
| SCHEMBL194767 | 0.90 | CCNA2 (0.35) | CCNA2CDK2CCNA1CDK5DYRK1A | |
| SCHEMBL588851 | 0.90 | CDK1 (0.34) | EGFRKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3046733 | 0.90 | HTR3A (0.36) | CDK2EGFRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3046737 | 0.90 | HTR3A (0.36) | CDK2EGFRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7715849 | 0.88 | SORD (0.31) | EGFRKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL194397 | 0.88 | SORD (0.31) | EGFRKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL516214 | 0.87 | SORD (0.39) | CCNA2CDK2CCNA1CDK5DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205609-B1 | HETEROCYCLE SUBSTITUTED PIPERAZINO DIHYDROTHIENO PYRIMIDINES | BOEHRINGER INGELHEIM INT (DE) | 2017-03-29 | — | — | EP | disclosed |
| WO-2011124524-A1 | COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4 INHIBITORS AND EP4 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-13 | — | — | WO | disclosed |
| WO-2009050242-A2 | HETEROCYCLE-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |