Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL194767 | 1.00 | CCNA2 (0.35) | CCNA2CDK2CCNA1CDK5DYRK1A | |
| Trifluoroacetic Acid SCHEMBL17019874 | 0.93 | CYP11B2 (0.34) | CCNA2CDK2CCNA1CDK5DYRK1A | |
| SCHEMBL7715595 | 0.90 | CCNA2 (0.33) | CCNA2CDK2CCNA1CDK5DYRK1A | |
| SCHEMBL194327 | 0.90 | CCNA2 (0.33) | CCNA2CDK2CCNA1CDK5DYRK1A | |
| SCHEMBL7715849 | 0.86 | SORD (0.31) | TRPV3KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL194397 | 0.86 | SORD (0.31) | TRPV3KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL17019875 | 0.85 | GPR6 (0.31) | — | |
| SCHEMBL3046733 | 0.85 | HTR3A (0.36) | CDK2TRPV3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3046737 | 0.85 | HTR3A (0.36) | CDK2TRPV3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL588851 | 0.85 | CDK1 (0.34) | TRPV3KDM4EALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011124524-A1 | COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4 INHIBITORS AND EP4 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-13 | — | — | WO | disclosed |
| WO-2010097332-A1 | DRUG COMBINATIONS CONTAINING PDE4 INHIBITORS AND NSAIDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |
| WO-2009050242-A2 | HETEROCYCLE-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |