Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27932128 | 0.93 | TSHR (0.69) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL23754643 | 0.93 | TSHR (0.60) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL27735819 | 0.91 | TSHR (0.71) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL5686979 | 0.90 | TSHR (0.74) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL5686970 | 0.90 | TSHR (0.74) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL27591414 | 0.89 | TSHR (0.56) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL27883678 | 0.88 | TSHR (0.77) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL5689405 | 0.87 | TSHR (0.59) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL27900968 | 0.86 | TSHR (0.80) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL5836895 | 0.85 | TSHR (0.67) | TSHRTHRBPOLBAPEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6367929-B1 | HIGH MOLECULAR WEIGHT HYDROPHILIC POLYMER (E.G., POLYVINYLPYRROLIDONE) IS ENTRAPPED IN A SILICONE HYDROGEL WITH LITTLE OR NO COVALENT BONDING BETWEEN IT AND THE HYDROGEL MATRIX. | JOHNSON & JOHNSON VISION CARE, INC. | 2002-04-09 | — | — | US | claimed |
| EP-3481897-B9 | SILICONE HYDROGELS COMPRISING POLYAMIDES | JOHNSON & JOHNSON VISION CARE (US) | 2024-04-10 | — | — | EP | disclosed |
| US-20240043598-A1 | POLYMER COMPOSITIONS CONTAINING GRAFTED POLYMERIC NETWORKS AND PROCESSES FOR THEIR PREPARATION AND USE | JOHNSON & JOHNSON VISION CARE (US) | 2024-02-08 | — | — | US | disclosed |
| EP-3481897-B1 | SILICONE HYDROGELS COMPRISING POLYAMIDES | JOHNSON & JOHNSON VISION CARE (US) | 2024-01-03 | — | — | EP | disclosed |
| EP-3481876-B9 | SILICONE HYDROGELS COMPRISING N-ALKYL METHACRYLAMIDES AND CONTACT LENSES MADE THEREOF | JOHNSON & JOHNSON VISION CARE (US) | 2023-12-13 | — | — | EP | disclosed |
| US-11829008-B2 | Increased stiffness center optic in soft contact lenses for astigmatism correction | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2023-11-28 | — | — | US | disclosed |
| US-11828913-B2 | Silicone hydrogels comprising polyamides | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2023-11-28 | — | — | US | disclosed |
| US-11820850-B2 | Polymer compositions containing grafted polymeric networks and processes for their preparation and use | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2023-11-21 | — | — | US | disclosed |
| EP-3481876-B1 | SILICONE HYDROGELS COMPRISING N-ALKYL METHACRYLAMIDES AND CONTACT LENSES MADE THEREOF | JOHNSON & JOHNSON VISION CARE (US) | 2023-09-27 | — | — | EP | disclosed |
| EP-3481877-B9 | SILICONE HYDROGELS COMPRISING HIGH LEVELS OF POLYAMIDES | JOHNSON & JOHNSON VISION CARE (US) | 2023-09-27 | — | — | EP | disclosed |
| EP-3094665-A1 | POLYMERS COMPRISING SULFONIC ACID GROUPS | Johnson & Johnson Vision Care, Inc. (US) | 2016-11-23 | — | — | EP | disclosed |
| US-20160313571-A1 | INCREASED STIFFNESS CENTER OPTIC IN SOFT CONTACT LENSES FOR ASTIGMATISM CORRECTION | JOHNSON & JOHNSON VISION CARE, INC. | 2016-10-27 | — | — | US | disclosed |
| US-9459377-B2 | Polymers comprising sulfonic acid groups | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2016-10-04 | — | — | US | disclosed |
| EP-2804909-B1 | SILICONE POLYMERS COMPRISING SULFONIC ACID GROUPS | JOHNSON & JOHNSON VISION CARE (US) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015108722-A1 | POLYMERS COMPRISING SULFONIC ACID GROUPS | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2015-07-23 | — | — | WO | disclosed |
| US-20150198744-A1 | POLYMERS COMPRISING SULFONIC ACID GROUPS | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2015-07-16 | — | — | US | disclosed |
| US-8940812-B2 | Silicone polymers comprising sulfonic acid groups | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2015-01-27 | — | — | US | disclosed |
| EP-2804909-A1 | SILICONE POLYMERS COMPRISING SULFONIC ACID GROUPS | Johnson & Johnson Vision Care Inc. (US) | 2014-11-26 | — | — | EP | disclosed |
| WO-2013109482-A1 | SILICONE POLYMERS COMPRISING SULFONIC ACID GROUPS | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-07-25 | — | — | WO | disclosed |
| US-20130184372-A1 | SILICONE POLYMERS COMPRISING SULFONIC ACID GROUPS | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-07-18 | — | — | US | disclosed |