Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438161 | 0.73 | POLB (0.33) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7641403 | 0.68 | SMN1; SMN2 (0.36) | NPC1RAB9AKDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL8849976 | 0.63 | LOXL2 (0.33) | SMN1; SMN2HTTGAA | |
| SCHEMBL12816288 | 0.62 | PTGS2 (0.31) | GAA | |
| Hydrochloric Acid SCHEMBL17836052 | 0.61 | — | — | |
| SCHEMBL12817753 | 0.61 | ESR1 (0.31) | — | |
| SCHEMBL13178144 | 0.61 | SMN1; SMN2 (0.56) | RAB9AL3MBTL1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7927391 | 0.60 | SMN1; SMN2 (0.38) | NPC1RAB9AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL192212 | 0.60 | HDAC2 (0.64) | NPC1RAB9ASMN1; SMN2HTTMEN1 | |
| SCHEMBL12441886 | 0.60 | HDAC2 (0.64) | NPC1RAB9ASMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376416-B1 | COORDINATION POLYMERIZATION CATALYSTS | JAPAN POLYCHEM CORPORATION (JP) | 2002-04-23 | — | — | US | disclosed |