Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7716638 | 1.00 | LMNA (0.37) | LMNAMETAP1HRH4ROCK2ROCK1 | |
| SCHEMBL8138459 | 0.90 | KDM4E (0.33) | LMNAMETAP1HRH4HPGDHTT | |
| SCHEMBL7714501 | 0.79 | LMNA (0.46) | LMNAMETAP1HRH4ROCK2ROCK1 | |
| SCHEMBL7716737 | 0.78 | ALDH1A1 (0.48) | LMNAMETAP1HRH4HPGDHTT | |
| SCHEMBL7714319 | 0.78 | LMNA (0.41) | LMNAMETAP1HRH4ROCK2ROCK1 | |
| SCHEMBL7714708 | 0.78 | LMNA (0.46) | LMNAMETAP1HRH4ROCK2ROCK1 | |
| SCHEMBL7708442 | 0.77 | LMNA (0.45) | LMNAMETAP1HRH4ROCK2ROCK1 | |
| SCHEMBL5202933 | 0.77 | L3MBTL1 (0.35) | HTTMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL5202927 | 0.77 | L3MBTL1 (0.35) | HTTMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL7714147 | 0.76 | ALDH1A1 (0.44) | LMNAMETAP1HRH4HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |