Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | IAPP | P10997 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31186853 | 1.00 | TRPA1 (0.45) | TRPA1ATMHPGDENPP2ALDH1A1 | |
| SCHEMBL28380698 | 0.87 | ALDH1A1 (0.45) | HPGDENPP2ALDH1A1MAPTPDCD1 | |
| SCHEMBL957760 | 0.82 | AR (0.41) | TRPA1ATMHPGDENPP2ALDH1A1 | |
| SCHEMBL28909080 | 0.79 | ALDH1A1 (0.46) | TRPA1HPGDENPP2ALDH1A1MAPT | |
| SCHEMBL3792645 | 0.79 | ESR1 (0.41) | TRPA1ATMHPGDENPP2ALDH1A1 | |
| SCHEMBL891289 | 0.79 | HSPA5 (0.54) | HPGDALDH1A1MAPTHSD17B10HSPA5 | |
| SCHEMBL845508 | 0.76 | HSPA5 (0.56) | TRPA1ATMHPGDALDH1A1MAPT | |
| SCHEMBL3072494 | 0.76 | ALDH1A1 (0.50) | TRPA1ATMHPGDALDH1A1HSD17B10 | |
| SCHEMBL23210828 | 0.76 | ALDH1A1 (0.38) | HPGDENPP2ALDH1A1PDCD1CD274 | |
| SCHEMBL3933757 | 0.76 | TSHR (0.43) | ATMHPGDENPP2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101723999-B | Method for total synthesis of icariin compounds | SHANGHAI SIJIYA PHARMACEUTICAL TECHNOLOGY CO LTD | 2012-05-09 | — | — | CN | disclosed |
| CN-101723999-A | Method for synthesizing epimedium herb glycosides | SHANGHAI SIJIYA PHARMACEUTICAL | 2010-06-09 | — | — | CN | disclosed |
| US-6376512-B1 | FOR TREATING PHYSIOLOGICAL CONDITION IN PATIENT WHEREIN SAID CONDITION IS ASSOCIATED WITH A PHYSIOLOGICALLY DETRIMENTAL LEVELS OF INSULIN, GLUCOSE, FREE FATTY ACIDS, OR TRIGLYCERIDES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-23 | — | — | US | disclosed |
| US-5059610-A | QUINOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4920132-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |