Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 3/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708894 | 0.92 | ADRB2 (0.32) | ADRB2ADRB3ADRB1GLARPS6KB1 | |
| SCHEMBL7714622 | 0.88 | — | — | |
| SCHEMBL7712721 | 0.86 | RPS6KB1 (0.30) | RPS6KB1 | |
| SCHEMBL7716950 | 0.85 | ADRB2 (0.32) | ADRB2ADRB3ADRB1ITGB1ITGA4 | |
| SCHEMBL7714945 | 0.84 | CYP3A4 (0.30) | CYP3A4 | |
| SCHEMBL7714803 | 0.84 | PDCD1 (0.33) | — | |
| SCHEMBL7714670 | 0.84 | ADRB2 (0.33) | ADRB2ADRB3ADRB1GLAITGB1 | |
| SCHEMBL7714532 | 0.82 | ADRB2 (0.32) | ADRB2ADRB3ADRB1CYP3A4 | |
| SCHEMBL7709011 | 0.81 | NR1H2 (0.32) | ADRB2ADRB3ADRB1ITGB1ITGA4 | |
| SCHEMBL7712843 | 0.80 | CTSS (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865421-B1 | ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS | GLAXO GROUP LTD (GB) | 2002-03-27 | — | — | EP | disclosed |
| US-6048872-A | DIETETICS; ANTIDIABETIC AGENTS; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS | GLAXO WELLCOME INC. (US) | 2000-04-11 | — | — | US | disclosed |