Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 9/20 | 1.00 |
| ▸ | KEAP1 | Q14145 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.87 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.87 |
| ▸ | MBOAT4 | Q96T53 | 4/20 | 0.83 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.83 |
| ▸ | USP7 | Q93009 | 2/20 | 0.83 |
| ▸ | USP2 | O75604 | 1/20 | 0.83 |
| ▸ | STAT3 | P40763 | 1/20 | 0.83 |
| ▸ | CCR6 | P51684 | 1/20 | 0.74 |
| ▸ | RORC | P51449 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bardoxolone SCHEMBL14140295 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL13569166 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL954253 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL69892 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL13827463 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL24337284 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL12447454 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL19236126 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL92342 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL16248344 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022126129-A1 | SYNTHETIC TRITERPENOIDS FOR USE IN THERAPY | REATA PHARMACEUTICALS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
| EP-2558105-B1 | BARDOXOLONE METHYL FOR THE TREATMENT OF OBESITY | REATA PHARMACEUTICALS INC (US) | 2019-11-20 | — | — | EP | disclosed |
| EP-3492077-A1 | SYNTHETIC TRITERPENOIDS AND METHODS OF USE IN THE TREATMENT OF DISEASE | Reata Pharmaceuticals, Inc. (US) | 2019-06-05 | — | — | EP | disclosed |
| EP-2279197-B1 | ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH SATURATION IN THE C-RING | REATA PHARMACEUTICALS INC (US) | 2014-11-05 | — | — | EP | disclosed |
| WO-2011130302-A2 | METHOD OF TREATING OBESITY USING ANTIOXIDANT INFLAMMATION MODULATORS | REATA PHARMACEUTICALS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2010011782-A1 | MONOCYCLIC CYANOENONES AND METHODS OF USE THEREOF | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2009146216-A2 | ANTIOXIDANT INFLAMMATION MODULATORS: NOVEL DERIVATIVES OF OLEANOLIC ACID | REATA PHARMACEUTICALS. INC. (US) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009129545-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH SATURATION IN THE C-RING | REATA PHARMACEUTICALS, INC. (US) | 2009-10-22 | — | — | WO | disclosed |
| WO-2009129546-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH AMINO AND OTHER MODIFICATIONS AT C-17 | REATA PHARMACEUTICALS, INC. (US) | 2009-10-22 | — | — | WO | disclosed |
| WO-2009089545-A1 | SYNTHETIC TRITERPENOIDS AND METHODS OF USE IN THE TREATMENT OF DISEASE | REATA PHARMACEUTICALS, INC. (US) | 2009-07-16 | — | — | WO | disclosed |
| EP-1089724-B1 | CYANO SUBSTITUTED OLEANOLIC ACID DERIVATIVES AS NO PRODUCTION INHIBITORS | DARTMOUTH COLLEGE (US) | 2009-05-06 | — | — | EP | disclosed |