Hydrochloric Acid

Hydrochloric Acid

SCHEMBL7717480

COc1ccc2c(c1)C([Zr+2](C1=CC=CC1)=C(c1ccccc1)c1ccccc1)c1ccccc1-2.[Cl-].[Cl-]

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 1/20 0.30
SLC6A3 known ✓ Q01959 1/20 0.30
GAA P10253 1/20 0.36
MAPT P10636 4/20 0.32
SMN1; SMN2 Q16637 4/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
TSHR P16473 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
GPR55 Q9Y2T6 1/20 0.32
SYK P43405 1/20 0.31
MTNR1A P48039 1/20 0.31
MTNR1B P49286 1/20 0.31
CYP1A2 P05177 2/20 0.31
CYP2D6 P10635 2/20 0.31
CYP2C19 P33261 2/20 0.31
CYP1A1 P04798 1/20 0.31
CYP2E1 P05181 1/20 0.31
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7717511 0.97 MAPT (0.33) GAAMAPTSMN1; SMN2NPC1RAB9A
Hydrochloric Acid SCHEMBL7711382 0.91 CYP2C9 (0.34) MAPTSMN1; SMN2NPC1RAB9AMEN1
Hydrochloric Acid SCHEMBL7717009 0.88 GAA (0.35) GAAMAPTTSHRMEN1KMT2A
Hydrochloric Acid SCHEMBL451011 0.88
Fluoride Ion SCHEMBL1130667 0.85
Hydrochloric Acid SCHEMBL8823193 0.84 GAA (0.33) GAAMAPTSMN1; SMN2NPC1RAB9A
Hydrochloric Acid SCHEMBL7715087 0.83 ALDH1A1 (0.31) ALDH1A1HPGD
Hydrochloric Acid SCHEMBL5083626 0.82 MEN1 (0.39) MAPTNPC1RAB9AMEN1KMT2A
Hydrochloric Acid SCHEMBL454870 0.82 TSHR (0.31) SMN1; SMN2TSHR
Hydrochloric Acid SCHEMBL7717524 0.82 MAPT (0.34) GAAMAPTRAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6372681-B1 METALLOCENE OF TRANSITION METAL AND; METAL OXIDE, SULFIDE, PHOSPHIDE, CARBIDE, NITRIDE, AND/OR SELENIDE; ORGANOALKALINE EARTH OR ZINC COMPOUND; AND ORGANOALUMINUM COMPOUND TOSOH CORPORATION (JP) 2002-04-16 US disclosed
US-6121396-A USING A METALLOCENE HAVING A SUBSTITUTED FLUORENYL GROUP, AND A COMPOUND REACTING WITH THE METALLOCENE TO FORM A CATIONIC METALLOCENE; HIGH- AND NARROW MOLECULAR WEIGHT; NARROW COMPOSITION DISTRIBUTION; PROCESS TEMPERATURE OF >120 C. TOSOH CORPORATION (JP) 2000-09-19 US disclosed
EP-0942006-A2 Catalyst for olefin polymer production and process for olefin polymer production employing the catalyst TOSOH CORPORATION (JP) 1999-09-15 EP disclosed