Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PRF1 | P14222 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737971 | 0.89 | KMT2A (0.40) | PARP10PARP1PRF1KDM4EMAOB | |
| SCHEMBL7706649 | 0.85 | PARP10 (0.38) | PARP10PARP1KDM4EMAOBALDH1A1 | |
| SCHEMBL7711040 | 0.78 | NPC1 (0.42) | KDM4EMAOBALDH1A1MAPTRXRA | |
| SCHEMBL14737290 | 0.78 | ALDH1A1 (0.40) | PRF1KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL7711047 | 0.77 | MRGPRX4 (0.43) | KDM4EALDH1A1 | |
| SCHEMBL14737152 | 0.74 | ALDH1A1 (0.48) | PARP10PARP1KDM4EALDH1A1MAPT | |
| SCHEMBL2591613 | 0.73 | MAOB (0.39) | KDM4EMAOB | |
| SCHEMBL14737128 | 0.72 | PRF1 (0.51) | PRF1MAOB | |
| SCHEMBL7713063 | 0.72 | PRF1 (0.53) | PRF1KDM4EMAOBMAPT | |
| SCHEMBL7714344 | 0.70 | PRF1 (0.53) | PRF1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |