Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710770 | 0.82 | AR (0.39) | CACNA1HS1PR3S1PR1ARSLC22A12 | |
| SCHEMBL7704750 | 0.76 | S1PR3 (0.39) | TRPA1EGLN2CACNA1HS1PR3S1PR1 | |
| SCHEMBL7714035 | 0.75 | FNTA (0.38) | KDM4D | |
| SCHEMBL7714038 | 0.75 | FNTA (0.38) | KDM4D | |
| SCHEMBL7714043 | 0.75 | FNTA (0.38) | KDM4D | |
| SCHEMBL7714845 | 0.73 | TRPA1 (0.44) | TRPA1EGLN2CACNA1HS1PR3S1PR1 | |
| SCHEMBL7736904 | 0.73 | S1PR3 (0.42) | CACNA1HS1PR3S1PR1 | |
| SCHEMBL7713179 | 0.73 | S1PR3 (0.41) | TRPA1EGLN2CACNA1HS1PR3S1PR1 | |
| Hydrochloric Acid SCHEMBL7220321 | 0.72 | FNTA (0.41) | CACNA1HS1PR3S1PR1 | |
| SCHEMBL7222226 | 0.71 | FNTA (0.41) | CACNA1HS1PR3S1PR1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |