Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 4/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.35 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709280 | 0.81 | ALDH1A1 (0.39) | NQO2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7714050 | 0.81 | CA12 (0.41) | NQO2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7715090 | 0.81 | NQO2 (0.49) | NQO2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL24150453 | 0.80 | NQO2 (0.42) | NQO2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL486774 | 0.80 | RXFP1 (0.42) | NQO2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL31680675 | 0.78 | TRPV1 (0.64) | NQO2MEN1RAB9AKMT2ATRPV1 | |
| SCHEMBL487254 | 0.78 | TRPV1 (0.64) | NQO2MEN1RAB9AKMT2ATRPV1 | |
| SCHEMBL24150706 | 0.77 | LCK (0.45) | NQO2NPC1RAB9ALCKCA12 | |
| SCHEMBL497320 | 0.77 | CXCR1 (0.43) | NQO2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL30190664 | 0.75 | LMNA (0.46) | MEN1NPC1RAB9AKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |