Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | ESRRA | P11474 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7721665 | 0.94 | FFAR4 (0.59) | FFAR4FFAR1PPARGPPARASIRT2 | |
| SCHEMBL2332168 | 0.92 | FFAR4 (0.47) | FFAR4FFAR1PPARGSIRT2SIRT1 | |
| SCHEMBL2327181 | 0.91 | PPARG (0.52) | FFAR4PPARGPPARASIRT2SIRT1 | |
| SCHEMBL9281680 | 0.88 | PDE3B (0.47) | FFAR4FFAR1PPARGPPARACYSLTR2 | |
| SCHEMBL2329776 | 0.87 | SIRT2 (0.51) | FFAR4PPARGPPARASIRT2SIRT1 | |
| SCHEMBL2327149 | 0.86 | FFAR4 (0.48) | FFAR4FFAR1PPARGSIRT2SIRT1 | |
| SCHEMBL9281733 | 0.85 | PDE3B (0.47) | PPARGPPARACYSLTR2CYSLTR1PDE3B | |
| SCHEMBL2211572 | 0.85 | G6PD (0.46) | FFAR4PPARGPPARAPDE3BPDE3A | |
| SCHEMBL4590119 | 0.84 | LTB4R (0.48) | FFAR4FFAR1PPARGPPARAPDE3B | |
| SCHEMBL2323904 | 0.84 | PPARA (0.48) | PPARGPPARAPDE3BPDE3AP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246808-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051473-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-07-19 | — | — | WO | disclosed |