Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 16/20 | 0.43 |
| ▸ | CFTR | P13569 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20178136 | 0.86 | TACR1 (0.55) | TACR1CFTRCYP2D6 | |
| SCHEMBL8706173 | 0.82 | TACR1 (0.40) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL9420087 | 0.82 | TACR1 (0.57) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL8701944 | 0.81 | TACR1 (0.47) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL8706570 | 0.81 | TACR1 (0.41) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL20178205 | 0.81 | TACR1 (0.46) | TACR1CFTRCYP2D6KCNH2HTR1A | |
| Hydrochloric Acid SCHEMBL6384500 | 0.79 | TACR1 (0.48) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL8682546 | 0.77 | TACR1 (0.42) | TACR1CFTRCYP2D6HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL8681413 | 0.76 | TACR1 (0.43) | TACR1CFTRCYP2D6KCNH2HTR1A | |
| Hydrochloric Acid SCHEMBL8610067 | 0.76 | CFTR (0.40) | TACR1CFTRCYP2D6HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376507-B1 | NERVE SYSTEM DISORDERS, AMYOTROPIC LATERAL SCLEROSIS | PFIZER INC. | 2002-04-23 | — | — | US | disclosed |