Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7716949 | 0.87 | MEN1 (0.52) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL8230863 | 0.80 | ALDH1A1 (0.52) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL22848339 | 0.80 | L3MBTL3 (0.56) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL10373626 | 0.79 | MAPT (0.77) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL7605419 | 0.78 | POLB (0.54) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL13698426 | 0.77 | ALDH1A1 (0.54) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL22175018 | 0.77 | KMT2A (0.62) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL22570271 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL24619071 | 0.77 | OPRL1 (0.49) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL22570043 | 0.75 | KMT2A (0.66) | ALDH1A1MAPTLMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372762-B1 | HETEROCYCLIC COMPOUNDS FOR NERVOUS SYSTEM DISORDERS | PFIZER INC. | 2002-04-16 | — | — | US | disclosed |
| EP-0953567-A2 | Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity | Pfizer Products Inc. (US) | 1999-11-03 | — | — | EP | disclosed |