Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7723830 | 0.97 | ALDH1A1 (0.34) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| SCHEMBL8468717 | 0.96 | ALDH1A1 (0.32) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| SCHEMBL7751696 | 0.96 | ALDH1A1 (0.32) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL4084545 | 0.75 | ALDH1A1 (0.33) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| SCHEMBL7748182 | 0.74 | ALDH1A1 (0.33) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28930333 | 0.72 | ALDH1A1 (0.58) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL6151674 | 0.71 | ALDH1A1 (0.39) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| SCHEMBL455687 | 0.69 | KDM4E (0.59) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL1074261 | 0.68 | ALDH1A1 (0.36) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL27613793 | 0.67 | KDM4E (0.56) | ALDH1A1KDM4EALOX15TSHRACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946609-B1 | POLYMERIZATION OF ETHYLENE WITH SPECIFIC IRON OR COBALT COMPLEXES, NOVEL PYRIDINEBIS(IMINES) AND NOVEL COMPLEXES OF PYRIDINEBIS(IMINES) WITH IRON AND COBALT | DU PONT (US) | 2002-02-27 | — | — | EP | disclosed |
| EP-1127897-A2 | Catalyst composition comprising specific iron or cobalt complexes and process for the oligomerization or polymerization of ethylene therewith | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2001-08-29 | — | — | EP | disclosed |