Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7720618 | 1.00 | IL1B (0.43) | IL1BMAPTRAB9ANPC1MEN1 | |
| SCHEMBL7732180 | 0.90 | IL1B (0.39) | IL1BMAPTRAB9ANPC1MEN1 | |
| SCHEMBL7732189 | 0.90 | IL1B (0.39) | IL1BMAPTRAB9ANPC1MEN1 | |
| SCHEMBL5873772 | 0.86 | RAB9A (0.43) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL5873767 | 0.86 | RAB9A (0.43) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL5432754 | 0.83 | ALDH1A1 (0.42) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL5432755 | 0.83 | ALDH1A1 (0.42) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL5427502 | 0.82 | DHODH (0.38) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL5427494 | 0.82 | DHODH (0.38) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL5873967 | 0.82 | DHODH (0.38) | MAPTRAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165514-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-01-02 | — | — | EP | claimed |
| WO-2000056710-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-28 | — | — | WO | claimed |