SCHEMBL7721046

SCHEMBL7721046

O=C1CCCCC(C(=O)c2cc(C(=O)C3CCCCC(=O)N3)cc(C(=O)C3CCCCC(=O)N3)c2)N1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.38
MCL1 Q07820 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.35
GAA P10253 1/20 0.34
HDAC3 O15379 2/20 0.34
HDAC1 Q13547 2/20 0.34
HDAC2 Q92769 2/20 0.34
HDAC10 Q969S8 2/20 0.34
HDAC11 Q96DB2 2/20 0.34
HDAC8 Q9BY41 2/20 0.34
HDAC6 Q9UBN7 2/20 0.34
MME P08473 6/20 0.33
ACE P12821 4/20 0.33
MAPK1 P28482 1/20 0.33
LMNA P02545 1/20 0.33
ECE1 P42892 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
NCOR2 Q9Y618 1/20 0.32
CNR2 P34972 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL991131 0.90 MCL1 (0.44) ABL1MCL1SMN1; SMN2MMEACE
SCHEMBL993051 0.89 MCL1 (0.45) ABL1MCL1SMN1; SMN2GAAMME
SCHEMBL9068188 0.89 ABL1 (0.34) ABL1MCL1SMN1; SMN2GAAHDAC3
SCHEMBL9621799 0.89 MCL1 (0.43) MCL1SMN1; SMN2MMEACEECE1
SCHEMBL10531994 0.88 MCL1 (0.44) ABL1MCL1SMN1; SMN2GAAMME
SCHEMBL1933595 0.88 MCL1 (0.44) ABL1MCL1SMN1; SMN2GAAMME
SCHEMBL9621802 0.88 ABL1 (0.34) ABL1MCL1SMN1; SMN2GAAHDAC3
SCHEMBL9005424 0.88 LMNA (0.37) ABL1MCL1SMN1; SMN2HDAC3HDAC1
SCHEMBL8014971 0.85 MCL1 (0.57) MCL1SMN1; SMN2GAAHDAC3HDAC1
SCHEMBL38409 0.85 MCL1 (0.57) MCL1SMN1; SMN2GAAHDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6498217-B1 HIGH MOLECULAR WEIGHT; FLOWABILITY; CRYSTALLINITY; STIFF; MOLDINGS BAYER AKTIENGESELLSHAFT (DE) 2002-12-24 US disclosed
EP-1078949-A1 Branching of polyamides with esters of carboxylic acid Bayer Aktiengesellschaft (DE) 2001-02-28 EP disclosed
EP-0202419-B1 LACTAM-BLOCK COPOLYMERS AlliedSignal Inc. (US) 1992-02-12 EP disclosed
US-4843127-A POLYCARBOXYLIC ACID WITH POLYETHER OR POLYSULFIDE ALLIED-SIGNAL INC. (US) 1989-06-27 US disclosed
US-4501861-A BLEND OF POLYCAPROLACTAM AND BLOCK POLYMER MONSANTO COMPANY (US) 1985-02-26 US disclosed
US-4346200-A Thermoplastic polyamide compositions MONSANTO COMPANY (US) 1982-08-24 US disclosed
US-4223112-A FIBERS, FOAMS, MOLDING MATERIALS MONSANTO COMPANY (US) 1980-09-16 US disclosed
US-RE30371-E POLYESTERAMIDES FROM ACYLLACTAMS AND ALCOHOLS, METAL ANIONIC CATALYSTS MONSANTO COMPANY (US) 1980-08-12 US disclosed
US-4034015-A LACTAM-POLYOL-POLYACYL LACTAM OR LACTAM-POLYOL-ACYL POLYLACTAM, BLOCK POLYMERS MONSANTO COMPANY (US) 1977-07-05 US disclosed
US-4031164-A LACTAM, POLYOL, POLYACYL LACTAM, CATALYST MONSANTO COMPANY (US) 1977-06-21 US disclosed
US-3993709-A LACTAM-POLYOL-POLYACYL LACTAM OR ACYL POLYLACTAM TERPOLYMERS MONSANTO COMPANY (US) 1976-11-23 US disclosed
US-3965075-A POLYAMIDEESTERS FROM N-ACYLLACTAMS AND ALCOHOLS; TERT-AMINE OR ORGANOMETALLIC CATALYST MONSANTO COMPANY 1976-06-22 US disclosed
US-3944629-A Polyester initiated anionic catalyzed polymerization of lactam MONSANTO COMPANY (US) 1976-03-16 US disclosed