SCHEMBL7721860

SCHEMBL7721860

Cc1ccccc1N(N=O)N=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
ACHE P22303 2/20 0.41
SIGMAR1 Q99720 1/20 0.39
ALDH1A1 P00352 4/20 0.39
LMNA P02545 2/20 0.38
CYP3A4 P08684 3/20 0.37
TRPM8 Q7Z2W7 1/20 0.37
ALOX15 P16050 1/20 0.36
C5AR1 P21730 1/20 0.35
ESR1 P03372 1/20 0.34
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
APAF1 O14727 1/20 0.33
NPC1 O15118 1/20 0.33
TDP2 O95551 1/20 0.33
NSD2 O96028 1/20 0.33
CYP1A2 P05177 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3690501 0.81 ALDH1A1 (0.46) TSHRACHESIGMAR1ALDH1A1LMNA
SCHEMBL1072174 0.79 ALDH1A1 (0.42) TSHRACHESIGMAR1ALDH1A1LMNA
SCHEMBL29728715 0.79 ALDH1A1 (0.42) TSHRACHESIGMAR1ALDH1A1LMNA
SCHEMBL3724687 0.77 SIGMAR1 (0.41) TSHRACHESIGMAR1ALDH1A1LMNA
SCHEMBL2303841 0.76 ALDH1A1 (0.45) TSHRALDH1A1LMNAALOX15C5AR1
SCHEMBL272718 0.76 TRPM8 (0.38) TSHRACHESIGMAR1ALDH1A1LMNA
SCHEMBL11506192 0.74 ALDH1A1 (0.61) TSHRACHESIGMAR1ALDH1A1LMNA
SCHEMBL11608388 0.73 CYP3A4 (0.51) SIGMAR1ALDH1A1LMNACYP3A4TRPM8
SCHEMBL5880644 0.71 CYP3A4 (0.41) TSHRALDH1A1CYP3A4ALOX15CA1
SCHEMBL516435 0.71 TSHR (0.53) TSHRACHESIGMAR1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6395943-B1 N-NITROSO INHIBITOR, ADDING A NITROPHENOL COMPOUND SELECTED FROM THE GROUP CONSISTING OF DINITROPHENOL, DINITROCRESOL, 2-SEC-BUTYL-4,6-DINITROPHENOL; STYRENE DURING ITS DISTILLATION UOP LLC 2002-05-28 US disclosed
EP-0269274-A2 Process for the preparation of thermoplastic elastomer compositions MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1988-06-01 EP disclosed
EP-0269275-A2 Thermoplastic elastomer composition MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1988-06-01 EP disclosed
EP-0266221-A2 Thermoplastic elastomer composition MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1988-05-04 EP disclosed