Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.48 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.45 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7577 | 0.90 | FFAR1 (0.43) | LPAR1LPAR2LPAR3PPARDFFAR1 | |
| SCHEMBL6707 | 0.89 | LPAR1 (0.41) | LPAR1LPAR2LPAR3LMNAGAA | |
| SCHEMBL6585 | 0.87 | EPHX1 (0.42) | LPAR1LPAR2LPAR3NR1H4RXRA | |
| SCHEMBL7741 | 0.84 | CYP4F2 (0.39) | LPAR1LPAR2LPAR3L3MBTL1ALDH1A1 | |
| SCHEMBL2265 | 0.83 | LPAR1 (0.49) | LPAR1LPAR2LPAR3ABCC4NR1H4 | |
| SCHEMBL1869 | 0.83 | LPAR1 (0.49) | LPAR1LPAR2LPAR3ABCC4NR1H4 | |
| SCHEMBL18597994 | 0.81 | LPAR1 (0.48) | LPAR1LPAR2LPAR3ABCC4LMNA | |
| SCHEMBL7024 | 0.80 | LPAR1 (0.48) | LPAR1LPAR2LPAR3ABCC4LMNA | |
| SCHEMBL1233 | 0.80 | CYP2C9 (0.42) | LPAR1ABCC4LMNATSHRALDH1A1 | |
| SCHEMBL2337 | 0.80 | CYP2C9 (0.42) | LPAR1ABCC4LMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | claimed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | claimed |
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |