Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741 | 0.91 | CYP4F2 (0.39) | LPAR1ALDH1A1LPAR2LPAR3L3MBTL1 | |
| SCHEMBL7722 | 0.89 | LPAR1 (0.48) | LPAR1ALDH1A1LPAR2LPAR3L3MBTL1 | |
| SCHEMBL6871 | 0.87 | EPHX1 (0.40) | ALDH1A1HTTTHRB | |
| SCHEMBL7577 | 0.83 | FFAR1 (0.43) | LPAR1LPAR2LPAR3 | |
| SCHEMBL1233 | 0.83 | CYP2C9 (0.42) | LPAR1ALDH1A1TSHRNPSR1KDM4E | |
| SCHEMBL2337 | 0.83 | CYP2C9 (0.42) | LPAR1ALDH1A1TSHRNPSR1KDM4E | |
| SCHEMBL18597759 | 0.83 | LPAR1 (0.42) | LPAR1ALDH1A1LPAR2LPAR3L3MBTL1 | |
| SCHEMBL6148 | 0.82 | ALDH1A1 (0.42) | LPAR1ALDH1A1LPAR2LPAR3L3MBTL1 | |
| SCHEMBL2265 | 0.79 | LPAR1 (0.49) | LPAR1ALDH1A1LPAR2LPAR3SMN1; SMN2 | |
| SCHEMBL1869 | 0.79 | LPAR1 (0.49) | LPAR1ALDH1A1LPAR2LPAR3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |