Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 1.00 |
| ▸ | MTNR1B | P49286 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | MAOA | P21397 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.57 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.57 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.57 |
| ▸ | FEN1 | P39748 | 1/20 | 0.57 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.57 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.55 |
| ▸ | ITK | Q08881 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31488126 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BKDM4EKMT2AMAOA | |
| SCHEMBL22616930 | 0.90 | MAOA (0.86) | MTNR1AMTNR1BKDM4EKMT2AMAOA | |
| SCHEMBL21318508 | 0.86 | KDM4E (0.76) | MTNR1AMTNR1BKDM4EKMT2AMAOA | |
| SCHEMBL21855490 | 0.85 | KDM4E (0.74) | MTNR1AMTNR1BKDM4EKMT2AMAOA | |
| SCHEMBL30227292 | 0.85 | KDM4E (0.74) | MTNR1AMTNR1BKDM4EKMT2AMAOA | |
| SCHEMBL19308451 | 0.85 | KDM4E (0.74) | MTNR1AMTNR1BKDM4EKMT2AMAOA | |
| Carbazole SCHEMBL28283104 | 0.85 | KMT2A (0.73) | MTNR1AMTNR1BKDM4EKMT2AMAOA | |
| SCHEMBL17117280 | 0.84 | KDM4E (0.73) | MTNR1AMTNR1BKDM4EKMT2AMAOA | |
| SCHEMBL7108858 | 0.83 | KDM4E (0.71) | MTNR1AMTNR1BKDM4EKMT2AMAOA | |
| SCHEMBL4729158 | 0.83 | KMT2A (0.71) | MTNR1AMTNR1BKDM4EKMT2AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220378740-A1 | COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF CARBAZOLE | IMMUNEBRIDGE LLC | 2022-12-01 | — | — | US | disclosed |
| EP-3962474-A1 | COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF CARBAZOLE | Transfusion Health LLC (US) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020223383-A1 | COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF CARBAZOLE | TRANSFUSION HEALTH, LLC (US) | 2020-11-05 | — | — | WO | disclosed |
| CN-111100061-A | Novel carbazole compound, preparation method and application thereof | 浙江海正药业股份有限公司 | 2020-05-05 | — | — | CN | disclosed |
| CN-106631969-B | The synthetic method of carbazole and its derivative | 江汉大学 | 2019-06-07 | — | — | CN | disclosed |
| CN-106631969-A | Synthetic method of carbazole and derivatives thereof | 江汉大学 | 2017-05-10 | — | — | CN | disclosed |
| CN-104974141-B | Carbazole tetrazole derivatives and its preparation method and application | 西南大学 | 2017-04-05 | — | — | CN | disclosed |
| CN-1829516-A | S 2-'4(phenylamino)-piperidin-1-yl!-n-phenyl-acetamine derivatives and related compounds as neuropeptide y5 (npy5) ligands for the treatement of obesity | ESTEVE LABOR DR (ES) | 2006-09-06 | — | — | CN | disclosed |
| US-6399631-B1 | 3-AMIDO OR 3-SULFONAMIDO; EATING DISORDERS IN HUMANS, DOGS AND CATS | PFIZER INC. | 2002-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220378740-A1 | COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF CARBAZOLE | HCLS1, MCL1, KIT | MTNR1A 4086/4885MTNR1B 3958/4885KDM4E 2595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.