Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723128 | 1.00 | SIGMAR1 (0.56) | SIGMAR1OPRM1CCR5LTA4HDRD4 | |
| SCHEMBL7724313 | 0.89 | CCR3 (0.49) | OPRM1DRD4 | |
| SCHEMBL7724321 | 0.89 | CCR3 (0.49) | OPRM1DRD4 | |
| SCHEMBL7719883 | 0.82 | SIGMAR1 (0.60) | SIGMAR1OPRM1DRD4OPRD1OPRK1 | |
| SCHEMBL7719877 | 0.82 | SIGMAR1 (0.60) | SIGMAR1OPRM1DRD4OPRD1OPRK1 | |
| SCHEMBL7719831 | 0.80 | SIGMAR1 (0.57) | SIGMAR1LTA4HDRD4DPP7CXCR3 | |
| SCHEMBL7719838 | 0.80 | SIGMAR1 (0.57) | SIGMAR1LTA4HDRD4DPP7CXCR3 | |
| SCHEMBL7817044 | 0.79 | OPRM1 (0.65) | OPRM1CCR5OPRD1OPRK1ADRA1A | |
| SCHEMBL7723968 | 0.79 | SIGMAR1 (0.58) | SIGMAR1OPRM1LTA4HDRD4DPP7 | |
| SCHEMBL7723967 | 0.79 | SIGMAR1 (0.58) | SIGMAR1OPRM1LTA4HDRD4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6468998-B1 | ANTAGONIZE SEROTONIN 2 RECEPTORS, SUPPRESS PLATELET AGGREGATION, IMPROVE PERIPHERAL CIRCULATION AND PROMOTE LACHRYMATION | MITSUBISHI PHARMA CORPORATION (JP) | 2002-10-22 | — | — | US | disclosed |
| EP-1125922-A1 | PYRROLIDINE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | Welfide Corporation (JP) | 2001-08-22 | — | — | EP | disclosed |