Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7731064 | 0.87 | ALDH1A1 (0.47) | CYP2C9CYP2C19CYP2D6MAPK1ALDH1A1 | |
| SCHEMBL7736141 | 0.86 | ALDH1A1 (0.46) | CYP2C9CYP2C19CYP2D6MAPK1ALDH1A1 | |
| SCHEMBL7736257 | 0.85 | ALDH1A1 (0.52) | CYP2C9CYP2C19CYP2D6MAPK1ALDH1A1 | |
| SCHEMBL7734109 | 0.85 | GRIN2B (0.54) | CYP2C9CYP2C19CYP2D6MAPK1ALDH1A1 | |
| SCHEMBL7733096 | 0.84 | ALDH1A1 (0.49) | CYP2C9CYP2C19CYP2D6MAPK1ALDH1A1 | |
| SCHEMBL7732339 | 0.84 | CYP2C9 (0.49) | CYP2C9CYP2C19CYP2D6MAPK1ALDH1A1 | |
| SCHEMBL7732672 | 0.77 | ACHE (0.64) | CYP2C9CYP2C19CYP2D6MAPK1ALDH1A1 | |
| SCHEMBL8124947 | 0.76 | CYP2C9 (0.49) | CYP2C9CYP2C19CYP2D6MAPK1ALDH1A1 | |
| SCHEMBL4577504 | 0.73 | GRIN1 (0.65) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL7734202 | 0.72 | CYP2D6 (0.52) | CYP2C9CYP2C19CYP2D6ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037890-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-27 | — | — | EP | claimed |
| WO-1999028318-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | claimed |
| US-6407122-B1 | NEUROPROTECTIVE AGENTS, ANTIISCHEMIC, AND HYPERGLYCEMIC AGENTS; HUNTINGTON*S, PARKINSON*S, AND ALZHEIMER*S DISEASE;AMYOTROPHIC LATERAL SCLEROSIS TREATMENT; NERVOUS SYSTEM AND BRAIN DISORDERS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-06-18 | — | — | US | disclosed |
| EP-1037890-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999028318-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |