Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | FAAH | O00519 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7720538 | 0.91 | HTR7 (0.44) | DRD3FAAHHTR7HTR2AHTR2C | |
| SCHEMBL7720555 | 0.90 | DRD3 (0.47) | DRD3FAAHHTR7HTR2AHTR2C | |
| SCHEMBL7720501 | 0.86 | GAA (0.47) | HTR7HTR2AHTR2CHTR1A | |
| SCHEMBL7720551 | 0.84 | DRD3 (0.43) | DRD3FAAHHTR7HTR2AHTR2C | |
| SCHEMBL6789349 | 0.83 | HTR7 (0.45) | DRD3HTR7HTR2AHTR2CHTR2B | |
| SCHEMBL7720585 | 0.83 | DRD3 (0.41) | DRD3FAAHHTR2AHTR2CDRD2 | |
| SCHEMBL7723358 | 0.82 | DRD2 (0.46) | DRD3HTR7HTR2AHTR2CDRD2 | |
| SCHEMBL7721461 | 0.81 | HTR2A (0.41) | DRD3FAAHHTR7HTR2AHTR2C | |
| SCHEMBL7719549 | 0.81 | KDM4E (0.43) | DRD3FAAHHTR7HTR2ADRD2 | |
| SCHEMBL7720317 | 0.81 | DRD2 (0.47) | DRD3HTR7DRD2DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228053-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION AND USE THEREOF AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001021604-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE-TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-29 | — | — | WO | disclosed |