Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.46 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723358 | 0.86 | DRD2 (0.46) | TP53HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL7723393 | 0.86 | DRD3 (0.43) | HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL6792965 | 0.85 | GAA (0.52) | GAALMNARXFP1CACNA1GREV1 | |
| SCHEMBL7720538 | 0.85 | HTR7 (0.44) | HTR7HTR2AHTR2C | |
| SCHEMBL7721461 | 0.84 | HTR2A (0.41) | HTR7HTR1AHTR2AHTR2CSLC6A4 | |
| SCHEMBL7720555 | 0.83 | DRD3 (0.47) | HTR7HTR2AHTR2C | |
| SCHEMBL7720551 | 0.81 | DRD3 (0.43) | GAAHTR7HTR1AHTR2AHTR2C | |
| SCHEMBL7723388 | 0.81 | DRD3 (0.42) | HTR7HTR1AHTR2AHTR2CSLC6A4 | |
| SCHEMBL7720317 | 0.79 | DRD2 (0.47) | CACNA1GHTR7HTR1ASLC6A4 | |
| SCHEMBL7719551 | 0.79 | DRD3 (0.45) | MAPTHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228053-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION AND USE THEREOF AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001021604-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE-TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-29 | — | — | WO | disclosed |