Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723561 | 1.00 | MALT1 (0.45) | MALT1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7723497 | 0.91 | ALDH1A1 (0.45) | KMT2AMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL7726371 | 0.91 | PLA2G2A (0.48) | KMT2AMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL7723499 | 0.91 | ALDH1A1 (0.45) | KMT2AMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL7726369 | 0.91 | PLA2G2A (0.48) | KMT2AMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL7724741 | 0.90 | KDM4E (0.50) | KMT2AMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL7724736 | 0.90 | KDM4E (0.50) | KMT2AMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL7725047 | 0.89 | CASP1 (0.47) | KMT2AMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL7725042 | 0.89 | CASP1 (0.47) | KMT2AMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL7723577 | 0.86 | MAPT (0.49) | KMT2AMAPTALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |