Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 5/20 | 0.49 |
| ▸ | MC4R | P32245 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7724046 | 1.00 | SIGMAR1 (0.54) | SIGMAR1DRD4MC4RSMN1; SMN2CXCR3 | |
| SCHEMBL7724049 | 1.00 | SIGMAR1 (0.54) | SIGMAR1DRD4MC4RSMN1; SMN2CXCR3 | |
| SCHEMBL7725083 | 0.89 | HTR2A (0.46) | SIGMAR1DRD4HTR2ADRD2 | |
| SCHEMBL7725075 | 0.89 | HTR2A (0.46) | SIGMAR1DRD4HTR2ADRD2 | |
| SCHEMBL7725077 | 0.89 | HTR2A (0.46) | SIGMAR1DRD4HTR2ADRD2 | |
| SCHEMBL7725101 | 0.88 | SIGMAR1 (0.61) | SIGMAR1DRD4MC4RSMN1; SMN2CXCR3 | |
| SCHEMBL7725104 | 0.88 | SIGMAR1 (0.61) | SIGMAR1DRD4MC4RSMN1; SMN2CXCR3 | |
| SCHEMBL7723951 | 0.84 | SIGMAR1 (0.49) | SIGMAR1DRD4MC4RSMN1; SMN2CXCR3 | |
| SCHEMBL7723953 | 0.84 | SIGMAR1 (0.49) | SIGMAR1DRD4MC4RSMN1; SMN2CXCR3 | |
| SCHEMBL7724247 | 0.82 | SIGMAR1 (0.60) | SIGMAR1DRD4MC4RSMN1; SMN2CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6468998-B1 | ANTAGONIZE SEROTONIN 2 RECEPTORS, SUPPRESS PLATELET AGGREGATION, IMPROVE PERIPHERAL CIRCULATION AND PROMOTE LACHRYMATION | MITSUBISHI PHARMA CORPORATION (JP) | 2002-10-22 | — | — | US | disclosed |
| EP-1125922-A1 | PYRROLIDINE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | Welfide Corporation (JP) | 2001-08-22 | — | — | EP | disclosed |