Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8463874 | 0.86 | DRD2 (0.34) | — | |
| Hydrochloric Acid SCHEMBL4658324 | 0.84 | CHRNB2 (0.32) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL3811780 | 0.82 | PDCD1 (0.31) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL29710451 | 0.82 | CHRNB2 (0.31) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL138389 | 0.82 | CHRNB2 (0.31) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL30203878 | 0.82 | CHRNB2 (0.31) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL6065118 | 0.82 | CHRNB2 (0.31) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL4660461 | 0.82 | CHRNB2 (0.31) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL29710448 | 0.82 | CHRNB2 (0.31) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL4659236 | 0.82 | CHRNB2 (0.31) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420501-B1 | POLYMERIZATION CATALYST ON SUPPORT | CHISSO CORPORATION (JP) | 2002-07-16 | — | — | US | disclosed |
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |
| EP-1026177-A1 | SUPPORTED METALLOCENE CATALYST, PROCESS FOR PREPARING THE SAME, AND PROCESS FOR PRODUCING OLEFIN POLYMERS | CHISSO CORPORATION (JP) | 2000-08-09 | — | — | EP | disclosed |