Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 6/20 | 0.35 |
| ▸ | CA2 | P00918 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | RECQL | P46063 | 3/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431300 | 0.83 | DBH (0.37) | DBHMAOAALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4652146 | 0.76 | — | — | |
| SCHEMBL11691899 | 0.74 | DBH (0.33) | DBHMAOAALDH1A1ALOX15HSD17B10 | |
| SCHEMBL11218287 | 0.74 | TSHR (0.38) | ALDH1A1TDP1LMNATSHRCA9 | |
| SCHEMBL1515006 | 0.74 | CA12 (0.31) | CA9CA12PARP1 | |
| SCHEMBL6362215 | 0.74 | — | — | |
| SCHEMBL1534020 | 0.74 | CYP1A2 (0.33) | ALDH1A1TDP1CA2CA1TSHR | |
| SCHEMBL4420230 | 0.74 | CES2 (0.33) | CA9CA12PARP1 | |
| SCHEMBL3293588 | 0.74 | ALDH1A1 (0.43) | ALDH1A1ALOX15HSD17B10TDP1HPGD | |
| SCHEMBL1153261 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014025993-A1 | INHIBITORS OF D-AMINO ACID OXIDASE | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-02-13 | — | — | WO | disclosed |
| US-6355805-B1 | MULTIBINDING COMPOUNDS USEFUL IN TREATMENT AND PREVENTION OF METABOLIC DISORDERS SUCH AS OBESITY AND DIABETES | ADVANCED MEDICINE, INC. | 2002-03-12 | — | — | US | disclosed |
| EP-1085894-A1 | BETA 3-ADRENERGIC RECEPTOR AGONISTS | Advanced Medicine, Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064053-A1 | β3-ADRENERGIC RECEPTOR AGONISTS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |
| EP-0003758-A1 | Etherified hydroxy-benzodiheterocycles and their acid addition salts, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1979-09-05 | — | — | EP | disclosed |