Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.45 |
| ▸ | PDE4A | P27815 | 6/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7724997 | 0.91 | CRHR1 (0.43) | MAP3K11DHODHMAPTHPGDSMN1; SMN2 | |
| SCHEMBL1926744 | 0.91 | GRIN1 (0.47) | MAP3K11DHODHMAPTHPGDSMN1; SMN2 | |
| SCHEMBL7720060 | 0.90 | HPGD (0.47) | MAP3K11MAPTHPGDSMN1; SMN2PDE4B | |
| SCHEMBL1925534 | 0.87 | GRIN1 (0.44) | DHODHMAPTHPGDSMN1; SMN2PDE4B | |
| SCHEMBL1924728 | 0.83 | CRHR1 (0.39) | KMT2AMEN1POLB | |
| SCHEMBL7720313 | 0.83 | DHODH (0.49) | DHODHMAPTHPGDSMN1; SMN2PDE4B | |
| SCHEMBL1925290 | 0.81 | GRIN1 (0.46) | MAP3K11DHODHMAPTHPGDSMN1; SMN2 | |
| SCHEMBL7720083 | 0.81 | GRIN1 (0.46) | MAP3K11MAPTHPGDSMN1; SMN2 | |
| SCHEMBL7723538 | 0.81 | CNR2 (0.44) | MAP3K11MAPTHPGDSMN1; SMN2 | |
| SCHEMBL7720077 | 0.78 | CASP1 (0.48) | MAPTHPGDKMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |