Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.43 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
| ▸ | KMO | O15229 | 4/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7724892 | 0.91 | MAP3K11 (0.48) | MAP3K11LMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL7723538 | 0.90 | CNR2 (0.44) | CRHR1CNR2KMOMAP3K11CRHR2 | |
| SCHEMBL1926744 | 0.88 | GRIN1 (0.47) | CRHR1CNR2MAP3K11CRHR2MAPT | |
| SCHEMBL1925534 | 0.84 | GRIN1 (0.44) | CNR2MAPTHPGDSMN1; SMN2PDE4B | |
| SCHEMBL7724730 | 0.84 | MAPT (0.44) | KMOLMNAMAPTPDE4APDE4B | |
| SCHEMBL7720060 | 0.81 | HPGD (0.47) | CRHR1CNR2MAP3K11LMNAMAPT | |
| SCHEMBL1924728 | 0.81 | CRHR1 (0.39) | CRHR1CNR2CRHR2 | |
| SCHEMBL1925290 | 0.79 | GRIN1 (0.46) | CRHR1CNR2MAP3K11LMNACRHR2 | |
| SCHEMBL7720083 | 0.78 | GRIN1 (0.46) | CRHR1CNR2MAP3K11CRHR2MAPT | |
| SCHEMBL7724744 | 0.78 | ALDH1A1 (0.43) | KMOLMNAMAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |