Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | PRKDC | P78527 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ERN1 | O75460 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20135982 | 0.86 | ALDH1A1 (0.63) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL2432873 | 0.85 | ALDH1A1 (0.47) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL668963 | 0.85 | ALDH1A1 (0.67) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL26107991 | 0.83 | ALDH1A1 (0.50) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL13618030 | 0.82 | TAAR1 (0.53) | TAAR1CYP3A4 | |
| SCHEMBL4813783 | 0.82 | ALDH1A1 (0.68) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL29950688 | 0.82 | ALDH1A1 (0.68) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL4071797 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL7720458 | 0.80 | TAAR1 (0.62) | TAAR1CYP3A4 | |
| SCHEMBL20022271 | 0.80 | ALDH1A1 (0.50) | ALDH1A1KDM4ETSHRTDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1255396-C | Carboxylic acid derivatives containing fused rings | EISAI CO LTD (JP) | 2006-05-10 | — | — | CN | disclosed |
| CN-1211361-C | Carboxylic acid derivatives containing fused rings | EISAI CO LTD (JP) | 2005-07-20 | — | — | CN | disclosed |
| CN-1548428-A | Carboxylic acid derivatives containing fused rings | ������������ʽ���� | 2004-11-24 | — | — | CN | disclosed |
| US-6358995-B1 | AGONIST FOR RETINOIC ACID RECEPTORS; CAN BE SUBSTITUTED FOR RETINOIC ACID AS PREVENTIVE AND THERAPEUTIC DRUGS FOR VARIOUS DISEASES OR CANCERS, SUCH AS ACUTE PROMYELOCYTIC LEUKEMIA. | EISAI CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6121309-A | SUCH AS 4-(2-(5-(7-FLUORO-4-TRIFLUOROMETHYLBENZOFURAN-2-YL)PYRROLYL)) BENZOIC ACID; RETINOIC ACID RECEPTOR AGONISM | EISAI CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| US-6110959-A | A RETINOIC ACID RECEPTOR AGONIST | EISAI CO., LTD. (JP) | 2000-08-29 | — | — | US | disclosed |
| CN-1214042-A | Carboxylic acid derivatives containing fused rings | EISAI CO LTD (JP) | 1999-04-14 | — | — | CN | disclosed |
| EP-0889032-A1 | FUSED-RING CARBOXYLIC ACID DERIVATIVES | Eisai Co., Ltd. (JP) | 1999-01-07 | — | — | EP | disclosed |