SCHEMBL7724946

SCHEMBL7724946

NC(=O)COc1ccc(CCC(=O)O)cc1-c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 8/20 0.56
FFAR1 O14842 7/20 0.51
FFAR4 Q5NUL3 5/20 0.51
PLA2G10 O15496 1/20 0.50
PLA2G2A P14555 1/20 0.50
SLCO1B1 Q9Y6L6 1/20 0.50
TP53 P04637 1/20 0.50
MDM2 Q00987 1/20 0.50
BCL2L1 Q07817 1/20 0.49
MCL1 Q07820 1/20 0.49
PSMD14 O00487 1/20 0.46
MMP2 P08253 1/20 0.46
BLM P54132 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7734112 0.92 PTGDR2 (0.53) PTGDR2FFAR1FFAR4PLA2G10PLA2G2A
SCHEMBL7735506 0.91 PTGDR2 (0.63) PTGDR2FFAR1FFAR4TP53MDM2
SCHEMBL7734080 0.90 PTGDR2 (0.52) PTGDR2PLA2G10PLA2G2APSMD14MMP2
SCHEMBL7735881 0.88 PTPN1 (0.56) PTGDR2TP53MDM2PSMD14MMP2
SCHEMBL7734849 0.85 PTGDR2 (0.53) PTGDR2FFAR1FFAR4TP53MDM2
SCHEMBL7734915 0.83 PTPN1 (0.48) PTGDR2PSMD14MMP2BLM
SCHEMBL7725122 0.83 PTGDR2 (0.60) PTGDR2FFAR1PLA2G10PLA2G2ATP53
SCHEMBL27404781 0.82 FFAR1 (0.51) PTGDR2FFAR1FFAR4
SCHEMBL7725124 0.81 FFAR1 (0.58) FFAR1FFAR4TP53MDM2
SCHEMBL7734883 0.81 TP53 (0.52) PTGDR2FFAR1FFAR4TP53MDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1103332-C Biphenyl-5-alkanoic acid derivs. and use thereof ASAHI CHEMICAL IND (JP) 2003-03-19 CN claimed
US-6376546-B1 ANTIALLERGENS ASAHI KASEI KABUSHIKI KAISHA (JP) 2002-04-23 US claimed
CN-1276778-A Biphenyl-5-alkanoic acid derivs. and use thereof ASAHI CHEMICAL IND (JP) 2000-12-13 CN claimed
EP-1024130-A1 BIPHENYL-5-ALKANOIC ACID DERIVATIVES AND USE THEREOF Asahi Kasei Kogyo Kabushiki Kaisha (JP) 2000-08-02 EP claimed
CN-1103332-C Biphenyl-5-alkanoic acid derivs. and use thereof ASAHI CHEMICAL IND (JP) 2003-03-19 CN disclosed
US-6376546-B1 ANTIALLERGENS ASAHI KASEI KABUSHIKI KAISHA (JP) 2002-04-23 US disclosed
CN-1276778-A Biphenyl-5-alkanoic acid derivs. and use thereof ASAHI CHEMICAL IND (JP) 2000-12-13 CN disclosed
EP-1024130-A1 BIPHENYL-5-ALKANOIC ACID DERIVATIVES AND USE THEREOF Asahi Kasei Kogyo Kabushiki Kaisha (JP) 2000-08-02 EP disclosed