Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15267699 | 0.84 | KMT2A (0.60) | ALDH1A1LMNAMAPTRAB9ANPC1 | |
| SCHEMBL13602760 | 0.83 | ALDH1A1 (0.53) | ALDH1A1LMNANOX1MAPTRAB9A | |
| SCHEMBL13370416 | 0.83 | KMT2A (0.65) | ALDH1A1LMNANOX1MAPTRAB9A | |
| SCHEMBL6390723 | 0.81 | CA1 (0.54) | ALDH1A1LMNANOX1MAPTRAB9A | |
| SCHEMBL7289846 | 0.81 | RAB9A (0.73) | ALDH1A1LMNANOX1MAPTRAB9A | |
| SCHEMBL14799129 | 0.81 | ALDH1A1 (0.56) | ALDH1A1LMNANOX1MAPTRAB9A | |
| SCHEMBL7827838 | 0.79 | CYP1A1 (0.64) | ALDH1A1LMNAMAPTRAB9ANPC1 | |
| SCHEMBL11638641 | 0.79 | SMN1; SMN2 (0.59) | ALDH1A1LMNAMAPTRAB9ANPC1 | |
| SCHEMBL12807727 | 0.79 | GAA (0.61) | ALDH1A1MAPTRAB9ANPC1KMT2A | |
| SCHEMBL2188394 | 0.79 | POLB (0.73) | ALDH1A1RAB9ANPC1NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |