Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.49 |
| ▸ | PTGIR | P43119 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7720077 | 0.90 | CASP1 (0.48) | CRHR1PTGIRL3MBTL1KMT2APOLB | |
| SCHEMBL7723523 | 0.88 | CRHR1 (0.51) | CRHR1PTGIRL3MBTL1RECQLNPC1 | |
| SCHEMBL7724779 | 0.87 | MAPT (0.53) | CRHR1PTGIRL3MBTL1POLBAPEX1 | |
| SCHEMBL7723691 | 0.86 | CRHR1 (0.49) | CRHR1PTGIRL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL7726552 | 0.86 | NPC1 (0.47) | CRHR1PTGIRL3MBTL1KMT2APOLB | |
| SCHEMBL7726406 | 0.86 | CYP3A4 (0.49) | CRHR1PTGIRSMN1; SMN2KMT2APOLB | |
| SCHEMBL7727026 | 0.84 | CRHR1 (0.50) | CRHR1PTGIRL3MBTL1SMN1; SMN2POLB | |
| SCHEMBL7724827 | 0.84 | TACR3 (0.52) | CRHR1L3MBTL1KMT2AMAPTNPC1 | |
| SCHEMBL1927375 | 0.84 | CRHR1 (0.39) | CRHR1PTGIRL3MBTL1KMT2AMEN1 | |
| SCHEMBL1925290 | 0.84 | GRIN1 (0.46) | CRHR1PTGIRSMN1; SMN2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |