Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PTGIR | P43119 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7720077 | 0.96 | CASP1 (0.48) | NPC1RAB9ANPBWR1CASP1CRHR1 | |
| SCHEMBL7723459 | 0.88 | CRHR1 (0.47) | NPC1RAB9ANPBWR1CRHR1KMT2A | |
| SCHEMBL7723511 | 0.87 | MAPT (0.51) | NPC1RAB9ANPBWR1CRHR1LMNA | |
| SCHEMBL7725143 | 0.86 | CRHR1 (0.46) | NPC1RAB9ANPBWR1CRHR1KMT2A | |
| SCHEMBL7724970 | 0.86 | CRHR1 (0.49) | NPC1RAB9ANPBWR1CRHR1KMT2A | |
| SCHEMBL7725153 | 0.84 | CRHR1 (0.47) | NPC1RAB9ANPBWR1CRHR1KMT2A | |
| SCHEMBL7723523 | 0.83 | CRHR1 (0.51) | NPC1RAB9ACRHR1LMNAL3MBTL1 | |
| SCHEMBL7724779 | 0.82 | MAPT (0.53) | NPC1RAB9ACRHR1LMNAL3MBTL1 | |
| SCHEMBL7724857 | 0.82 | L3MBTL1 (0.50) | NPC1RAB9AKMT2AL3MBTL1KDM4E | |
| SCHEMBL7723691 | 0.81 | CRHR1 (0.49) | NPC1RAB9ACRHR1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |