Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7726101 | 1.00 | HSD17B10 (0.34) | HSD17B10NFKB1NFKB2RELANR1H2 | |
| SCHEMBL7727961 | 1.00 | HSD17B10 (0.34) | HSD17B10NFKB1NFKB2RELANR1H2 | |
| SCHEMBL7733526 | 0.89 | PTPN1 (0.39) | NFKB1NFKB2RELANR1H2SMN1; SMN2 | |
| SCHEMBL7733813 | 0.89 | PTPN1 (0.39) | NFKB1NFKB2RELANR1H2SMN1; SMN2 | |
| SCHEMBL7726393 | 0.89 | PTPN1 (0.39) | NFKB1NFKB2RELANR1H2SMN1; SMN2 | |
| SCHEMBL7722230 | 0.88 | HSD17B10 (0.40) | HSD17B10NFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL7722056 | 0.88 | HSD17B10 (0.40) | HSD17B10NFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL7727566 | 0.85 | HTRA1 (0.34) | HSD17B10NR1H2SMN1; SMN2HTRA1HSD11B1 | |
| SCHEMBL7727102 | 0.83 | USP30 (0.40) | NR1H2HTRA1UCHL1 | |
| SCHEMBL7726796 | 0.83 | USP30 (0.40) | NR1H2HTRA1UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |
| WO-2000001714-A1 | EFFLUX PUMP INHIBITORS | MICROCIDE PHARMACEUTICALS, INC. (US) | 2000-01-13 | — | — | WO | disclosed |