Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7722230 | 1.00 | HSD17B10 (0.40) | HSD17B10SMN1; SMN2HSD11B1KLK7AGTR2 | |
| SCHEMBL7729134 | 0.90 | PTPN1 (0.38) | HSD17B10SMN1; SMN2HSD11B1AGTR2MEN1 | |
| SCHEMBL7729049 | 0.90 | PTPN1 (0.38) | HSD17B10SMN1; SMN2HSD11B1AGTR2MEN1 | |
| SCHEMBL7727961 | 0.88 | HSD17B10 (0.34) | HSD17B10SMN1; SMN2HSD11B1AGTR2NFKB1 | |
| SCHEMBL7728185 | 0.88 | HSD17B10 (0.34) | HSD17B10SMN1; SMN2HSD11B1AGTR2NFKB1 | |
| SCHEMBL7726101 | 0.88 | HSD17B10 (0.34) | HSD17B10SMN1; SMN2HSD11B1AGTR2NFKB1 | |
| SCHEMBL7733813 | 0.78 | PTPN1 (0.39) | SMN1; SMN2HSD11B1NFKB1NFKB2RELA | |
| SCHEMBL7726393 | 0.78 | PTPN1 (0.39) | SMN1; SMN2HSD11B1NFKB1NFKB2RELA | |
| SCHEMBL7733526 | 0.78 | PTPN1 (0.39) | SMN1; SMN2HSD11B1NFKB1NFKB2RELA | |
| SCHEMBL7730860 | 0.76 | NFKB1 (0.34) | HSD17B10HSD11B1NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |