Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.64 |
| ▸ | CTSS | P25774 | 6/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7722248 | 0.87 | CTSK (0.62) | CTSKCTSSHDAC4HDAC1HDAC8 | |
| SCHEMBL12890034 | 0.85 | CTSS (0.74) | CTSKCTSSHDAC4HDAC1HDAC8 | |
| SCHEMBL6550878 | 0.85 | CTSS (0.74) | CTSKCTSSHDAC4HDAC1HDAC8 | |
| SCHEMBL13669553 | 0.85 | CTSS (0.74) | CTSKCTSSHDAC4HDAC1HDAC8 | |
| SCHEMBL8695864 | 0.83 | CTSK (0.63) | CTSKCTSSHDAC4HDAC1HDAC8 | |
| SCHEMBL4374188 | 0.82 | CTSS (0.74) | CTSKCTSSHDAC8CTSBCTSL | |
| SCHEMBL4365866 | 0.82 | CTSS (0.74) | CTSKCTSSHDAC8CTSBCTSL | |
| SCHEMBL18661099 | 0.82 | CTSS (0.74) | CTSKCTSSHDAC8CTSBCTSL | |
| SCHEMBL7726821 | 0.81 | CTSK (0.58) | CTSKCTSSHDAC4HDAC1HDAC8 | |
| SCHEMBL1979805 | 0.81 | CTSS (0.72) | CTSKCTSSCTSBCTSLSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |
| WO-2000001714-A1 | EFFLUX PUMP INHIBITORS | MICROCIDE PHARMACEUTICALS, INC. (US) | 2000-01-13 | — | — | WO | disclosed |