Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 5/20 | 0.43 |
| ▸ | F10 | P00742 | 3/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7727250 | 0.91 | LTA4H (0.45) | SIRT2HDAC8POLBGHSRLTA4H | |
| SCHEMBL7731475 | 0.85 | HDAC8 (0.44) | HDAC8POLBGHSR | |
| SCHEMBL7726519 | 0.85 | POLB (0.42) | HDAC8POLB | |
| SCHEMBL7731723 | 0.84 | HDAC8 (0.44) | HDAC8POLB | |
| SCHEMBL7729234 | 0.81 | HDAC4 (0.44) | HDAC8POLB | |
| SCHEMBL7722104 | 0.80 | PABPC1 (0.45) | HDAC8POLB | |
| SCHEMBL7728407 | 0.80 | MEN1 (0.39) | SIRT2HDAC8POLB | |
| SCHEMBL7728411 | 0.80 | MEN1 (0.39) | SIRT2HDAC8POLB | |
| SCHEMBL7725703 | 0.79 | POLB (0.43) | HDAC8POLB | |
| SCHEMBL7728188 | 0.79 | POLB (0.47) | HDAC8POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |