Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461012 | 0.71 | GAA (0.48) | GAAKDM4EMEN1KMT2AUSP2 | |
| SCHEMBL10622430 | 0.70 | KDM4E (0.48) | GAAKDM4EMEN1KMT2AUSP2 | |
| SCHEMBL15637454 | 0.63 | ADORA2A (0.43) | GAAKDM4EMEN1KMT2AHTT | |
| SCHEMBL15637243 | 0.63 | NPC1 (0.42) | KDM4EMEN1KMT2AUSP2TP53 | |
| SCHEMBL11785056 | 0.62 | ALDH1A1 (0.54) | KDM4EMEN1KMT2AUSP2TP53 | |
| SCHEMBL10824202 | 0.62 | KMT2A (0.67) | GAAKDM4EMEN1KMT2AUSP2 | |
| SCHEMBL14688616 | 0.59 | PDE10A (0.43) | GAAKDM4EMEN1KMT2AUSP2 | |
| SCHEMBL3294567 | 0.59 | KCNN4 (0.45) | GAAKDM4EMEN1KMT2AUSP2 | |
| SCHEMBL1531523 | 0.59 | MAPK1 (0.56) | GAAKDM4EMEN1KMT2AUSP2 | |
| SCHEMBL9435417 | 0.59 | GAA (0.60) | GAAKDM4EMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1146561-C | Pyrimidine derivatives having antitumor activity | 盐野义制药株式会社 | 2004-04-21 | — | — | CN | disclosed |
| US-6420367-B1 | RAS GENE | SHIONOGO & CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| CN-1317003-A | Pyrimidine derivatives having antitumor activity | SHIONOGI & CO (JP) | 2001-10-10 | — | — | CN | disclosed |
| EP-1097933-A1 | PYRIMIDINE DERIVATIVES EXHIBITING ANTITUMOR ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2001-05-09 | — | — | EP | disclosed |